Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.57 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8272011 | 0.84 | PDE10A (0.62) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8271489 | 0.81 | PDE10A (0.63) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8271479 | 0.80 | PDE10A (0.66) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2558017 | 0.80 | PDE10A (0.58) | PDE10AALDH1A1LMNAKDM4EMAOA | |
| SCHEMBL8271931 | 0.78 | PDE10A (0.64) | PDE10AALDH1A1LMNAKDM4EMAOA | |
| SCHEMBL7705223 | 0.78 | PDE10A (0.59) | PDE10AALDH1A1LMNAKDM4EMAOA | |
| SCHEMBL8271478 | 0.78 | PDE10A (0.63) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8272031 | 0.77 | PDE10A (0.59) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8271339 | 0.77 | PDE10A (0.59) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8271493 | 0.77 | PDE10A (0.65) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | claimed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |