Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.57 |
| ▸ | STK17B | O94768 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562066 | 0.88 | NPC1 (0.57) | MEN1KMT2AMAPK1ALDH1A1ALOX15 | |
| SCHEMBL2553329 | 0.87 | RAB9A (0.67) | MEN1KMT2AMAPK1ALDH1A1HSD17B10 | |
| SCHEMBL19837768 | 0.84 | MEN1 (0.64) | MEN1KMT2AMAPK1ALDH1A1ALOX15 | |
| SCHEMBL18029526 | 0.84 | MEN1 (0.64) | MEN1KMT2AMAPK1ALDH1A1ALOX15 | |
| SCHEMBL2558952 | 0.84 | NPC1 (0.88) | MEN1KMT2AALDH1A1HSD17B10POLB | |
| SCHEMBL2559385 | 0.83 | RAB9A (0.69) | MEN1KMT2AMAPK1ALDH1A1HSD17B10 | |
| SCHEMBL2556997 | 0.83 | KDM4E (0.63) | MEN1KMT2AALDH1A1HSD17B10POLB | |
| SCHEMBL2557174 | 0.83 | PTK2 (0.57) | MEN1KMT2AMAPK1ALDH1A1HSD17B10 | |
| SCHEMBL18029531 | 0.81 | MEN1 (1.00) | MEN1KMT2AMAPK1ALDH1A1ALOX15 | |
| SCHEMBL2553531 | 0.81 | KDM4E (0.61) | MEN1KMT2AALDH1A1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |