Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | CDC25A | P30304 | 1/20 | 0.60 |
| ▸ | CDC25B | P30305 | 1/20 | 0.60 |
| ▸ | CDC25C | P30307 | 1/20 | 0.60 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559385 | 0.90 | RAB9A (0.69) | RAB9ANPC1LMNAALDH1A1MAPK1 | |
| SCHEMBL2559911 | 0.88 | LMNA (0.66) | RAB9ANPC1LMNAALDH1A1MAPK1 | |
| SCHEMBL2557032 | 0.88 | KDM4E (0.56) | RAB9ANPC1LMNAALDH1A1MAPK1 | |
| SCHEMBL2558952 | 0.88 | NPC1 (0.88) | RAB9ANPC1LMNAALDH1A1HPGD | |
| SCHEMBL18426612 | 0.87 | RAB9A (0.72) | RAB9ANPC1LMNAALDH1A1MAPK1 | |
| SCHEMBL2556997 | 0.87 | KDM4E (0.63) | RAB9ANPC1LMNAALDH1A1HSD17B10 | |
| SCHEMBL2558080 | 0.87 | MEN1 (0.68) | RAB9ANPC1ALDH1A1MAPK1HPGD | |
| SCHEMBL2562374 | 0.87 | RAB9A (0.59) | RAB9ANPC1LMNAALDH1A1HPGD | |
| SCHEMBL18425955 | 0.86 | RAB9A (0.64) | RAB9ANPC1LMNAALDH1A1MAPK1 | |
| SCHEMBL2558993 | 0.86 | KDM4E (0.56) | RAB9ANPC1LMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |