Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11112921 | 0.85 | AKR1B1 (0.52) | AKR1B1TDP1MAPTRXRARXRB | |
| SCHEMBL28215681 | 0.85 | ALDH1A1 (0.46) | AKR1B1MAPTALDH1A1TP53GAA | |
| SCHEMBL3329126 | 0.84 | GAA (0.48) | AKR1B1TDP1MAPTALDH1A1TP53 | |
| SCHEMBL27843772 | 0.83 | KMT2A (0.49) | TDP1MAPTALDH1A1TP53GAA | |
| SCHEMBL28473340 | 0.83 | AKR1B1 (0.46) | AKR1B1TDP1MAPTALDH1A1TP53 | |
| SCHEMBL2500577 | 0.82 | GAA (0.47) | AKR1B1MAPTALDH1A1TP53GAA | |
| SCHEMBL31644190 | 0.82 | TDP1 (0.56) | AKR1B1TDP1MAPTALDH1A1TP53 | |
| SCHEMBL5698045 | 0.81 | KEAP1 (0.48) | TDP1MAPTALDH1A1TP53GAA | |
| SCHEMBL9515865 | 0.81 | AKR1B1 (0.52) | AKR1B1TDP1MAPTALDH1A1TSHR | |
| SCHEMBL6639953 | 0.79 | KDM4E (0.44) | TDP1MAPTALDH1A1TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111777520-B | Synthesis method of multi-substituted dimethylamino phenyl acetic acid compound | 苏州爱玛特生物科技有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-111777520-A | Synthesis method of multi-substituted dimethylamino phenyl acetic acid compound | 苏州爱玛特生物科技有限公司 | 2020-10-16 | — | — | CN | claimed |
| CN-112574061-B | TRPV1 agonist and preparation method and application thereof | 南京清普生物科技有限公司 | 2023-05-19 | — | — | CN | disclosed |
| CN-111777520-B | Synthesis method of multi-substituted dimethylamino phenyl acetic acid compound | 苏州爱玛特生物科技有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-111777520-B | Synthesis method of multi-substituted dimethylamino phenyl acetic acid compound | 苏州爱玛特生物科技有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-111777520-B | Synthesis method of multi-substituted dimethylamino phenyl acetic acid compound | 苏州爱玛特生物科技有限公司 | 2023-04-07 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-11225655-B2 | Bi-functional complexes and methods for making and using such complexes | NUEVOLUTION A/S (DK) | 2022-01-18 | — | — | US | disclosed |
| EP-3020717-B1 | P2X4 RECEPTOR ANTAGONIST | NIPPON CHEMIPHAR CO (JP) | 2021-12-15 | — | — | EP | disclosed |
| CN-111777520-A | Synthesis method of multi-substituted dimethylamino phenyl acetic acid compound | 苏州爱玛特生物科技有限公司 | 2020-10-16 | — | — | CN | disclosed |
| CN-111777520-A | Synthesis method of multi-substituted dimethylamino phenyl acetic acid compound | 苏州爱玛特生物科技有限公司 | 2020-10-16 | — | — | CN | disclosed |
| US-5624950-A | USEFUL IN TREATMENT OF ANALGESIA, INFLAMMATION, ASTHMA, ALLERGIES, CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, IMMUNE SYSTEM DISORDERS, ANTISPASMODIC AGENTS, ANTIEMETIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 1997-04-29 | — | — | US | disclosed |
| EP-0758013-A1 | Liquid crystalline optical film, compensating film for liquid crystal display and liquid crystal display | NIPPON OIL COMPANY, LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |
| US-5508433-A | Derivatives of perhydroisoindole and preparation thereof | RHONE-POULENC RORER S.A. (FR) | 1996-04-16 | — | — | US | disclosed |
| US-5484942-A | Thiopyranopyrrole derivatives | RHONE-POULENC RORER S.A. (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5484804-A | Perhydroisoindole derivatives as antagonists of substance P | RHONE-POULENC RORER S.A. (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5463077-A | Exhibit substance P antagonist activity | RHONE-POULENC RORER S.A. (FR) | 1995-10-31 | — | — | US | disclosed |
| US-5451601-A | Perhydroisoindole derivatives and pharmaceutical compositions containing them | RHONE-POULENC RORER S.A. (FR) | 1995-09-19 | — | — | US | disclosed |
| US-5112988-A | ISOINDOLONE DERIVATIVES | RHONE-POULENC SANTE (FR) | 1992-05-12 | — | — | US | disclosed |
| US-5102667-A | Antiallergens, antiinflammatory agents, nervous system disorders, immunology, psychological disorders | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | disclosed |