Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | BACE1 | P56817 | 15/20 | 0.45 |
| ▸ | CTSD | P07339 | 9/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559401 | 0.80 | BACE1 (0.42) | MAPTBACE1CTSD | |
| SCHEMBL29889779 | 0.68 | CYP2A6 (0.55) | MAPTCYP11B2CYP11B1 | |
| SCHEMBL7710659 | 0.68 | BACE1 (0.70) | BACE1CTSD | |
| SCHEMBL29889660 | 0.68 | MAPT (0.49) | MAPTBACE1CTSDCYP11B2CYP11B1 | |
| SCHEMBL2489325 | 0.68 | MAPT (0.49) | MAPTBACE1CTSDCYP11B2CYP11B1 | |
| SCHEMBL3274614 | 0.68 | BACE1 (0.81) | BACE1CTSD | |
| SCHEMBL2371711 | 0.67 | BACE1 (0.41) | MAPTBACE1CTSDCYP11B2 | |
| SCHEMBL30150912 | 0.67 | CYP11B2 (0.45) | MAPTBACE1CTSDCYP11B2CYP11B1 | |
| SCHEMBL30150911 | 0.67 | CYP11B2 (0.45) | MAPTBACE1CTSDCYP11B2CYP11B1 | |
| SCHEMBL3881160 | 0.64 | CYP11B2 (0.50) | MAPTCYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |