Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.42 |
| ▸ | CTSD | P07339 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558533 | 0.80 | MAPT (0.49) | BACE1CTSDMAPT | |
| SCHEMBL4038495 | 0.78 | LMNA (0.52) | MAPTDHODHLMNA | |
| SCHEMBL2371711 | 0.64 | BACE1 (0.41) | BACE1CTSDMAPT | |
| SCHEMBL29889779 | 0.64 | CYP2A6 (0.55) | MAPTLMNA | |
| SCHEMBL4043208 | 0.63 | LMNA (0.70) | LMNA | |
| SCHEMBL24631747 | 0.62 | LMNA (0.40) | MAPTLMNA | |
| SCHEMBL3274614 | 0.62 | BACE1 (0.81) | BACE1CTSD | |
| Hydrochloric Acid SCHEMBL4045240 | 0.62 | LMNA (0.68) | LMNA | |
| SCHEMBL2372090 | 0.61 | BACE1 (0.49) | BACE1CTSD | |
| SCHEMBL2827619 | 0.61 | LMNA (0.59) | MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |