SCHEMBL2558622

SCHEMBL2558622

CC(=O)CC(=O)Nc1cc(C(=O)O)ccc1C

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SELL P14151 2/20 0.62
SELP P16109 2/20 0.62
SELE P16581 1/20 0.59
CASR P41180 1/20 0.53
L3MBTL1 Q9Y468 2/20 0.52
KMT2A Q03164 4/20 0.51
MEN1 O00255 3/20 0.51
ATM Q13315 1/20 0.51
ALDH1A1 P00352 4/20 0.50
KDM4E B2RXH2 2/20 0.50
PTPN1 P18031 3/20 0.49
MAPT P10636 2/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
GAA P10253 1/20 0.49
MAPK1 P28482 1/20 0.49
LMNA P02545 1/20 0.48
ALOX12 P18054 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2558174 0.87 MEN1 (0.56) SELLSELPSELEKMT2AMEN1
SCHEMBL7139150 0.86 MAPK14 (0.50) SELLSELPSELECASRL3MBTL1
SCHEMBL7078702 0.84 KDM4E (0.51) SELLSELPSELEKMT2AMEN1
SCHEMBL560143 0.83 L3MBTL1 (0.57) SELLSELPSELECASRL3MBTL1
SCHEMBL11547275 0.83 HDAC1 (0.57) L3MBTL1KMT2AMEN1ALDH1A1MAPT
SCHEMBL2556020 0.83 EP300 (0.51) SELLSELPSELEL3MBTL1KMT2A
SCHEMBL7530798 0.83 ALDH1A1 (0.57) CASRL3MBTL1KMT2AMEN1ALDH1A1
SCHEMBL14426473 0.83 SELL (0.65) SELLSELPSELECASRL3MBTL1
SCHEMBL13184790 0.82 MAPK14 (0.60)
SCHEMBL1577190 0.81 HDAC3 (0.62) KMT2AMEN1ALDH1A1GAALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed
US-4474609-A Recrystallization-resistant monoazo pigment mixtures of high tinctorial strength, process for their preparation and their use HOECHST AKTIENGESELLSCHAFT (DE) 1984-10-02 US disclosed