Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21671809 | 0.89 | POLB (0.44) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL23589790 | 0.84 | RAB9A (0.50) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL18737257 | 0.81 | RAB9A (0.44) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL12255679 | 0.78 | L3MBTL1 (0.53) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL77481 | 0.78 | KDM4E (0.47) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL2737128 | 0.77 | TSHR (0.51) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL14925205 | 0.76 | KDM4E (0.42) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL6370552 | 0.75 | KDM4E (0.40) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL12139578 | 0.74 | MAPT (0.49) | RAB9APOLBKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL17358383 | 0.74 | POLB (0.41) | RAB9APOLBKDM4ETSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | YAP1, TERF2IP, TEAD1 | RAB9A 1789/4885POLB 1569/4885KDM4E 2608/4885 |
| US-20230174538-A1 | Tricyclic heterocycles | YAP1, TEAD1, TERF2IP | RAB9A 1456/4885POLB 1991/4885KDM4E 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.