Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTO1 | P78417 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2554209 | 0.87 | GSTO1 (0.60) | GSTO1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2551304 | 0.86 | RAB9A (0.54) | GSTO1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2560003 | 0.86 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2LMNATYR | |
| SCHEMBL2562423 | 0.86 | SMN1; SMN2 (0.54) | GSTO1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2556947 | 0.85 | VCP (0.52) | RAB9ANPC1SMN1; SMN2LMNATYR | |
| SCHEMBL2554473 | 0.83 | KDM4E (0.57) | GSTO1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2557174 | 0.83 | PTK2 (0.57) | RAB9ANPC1SMN1; SMN2LMNATYR | |
| SCHEMBL2559778 | 0.83 | RAB9A (0.51) | GSTO1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2558995 | 0.82 | HDAC3 (0.57) | RAB9ANPC1SMN1; SMN2LMNATYR | |
| SCHEMBL2557295 | 0.82 | SMN1; SMN2 (0.50) | RAB9ANPC1SMN1; SMN2LMNATYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |