Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.74 |
| ▸ | GPR88 | Q9GZN0 | 5/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12666568 | 1.00 | RIPK1 (0.74) | RIPK1GPR88KCNQ3KCNQ2CYP1A2 | |
| SCHEMBL25587390 | 1.00 | RIPK1 (0.74) | RIPK1GPR88KCNQ3KCNQ2CYP1A2 | |
| SCHEMBL4335710 | 0.90 | RIPK1 (0.74) | RIPK1GPR88KCNQ3KCNQ2EPHX2 | |
| SCHEMBL25590886 | 0.87 | RIPK1 (0.67) | RIPK1GPR88KCNQ3KCNQ2CYP1A2 | |
| SCHEMBL12666549 | 0.86 | RIPK1 (0.60) | RIPK1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17882274 | 0.85 | RIPK1 (1.00) | RIPK1GPR88KCNQ3KCNQ2EPHX2 | |
| SCHEMBL17874150 | 0.85 | RIPK1 (1.00) | RIPK1GPR88KCNQ3KCNQ2EPHX2 | |
| SCHEMBL7820171 | 0.85 | RIPK1 (0.55) | RIPK1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL684799 | 0.83 | RIPK1 (0.54) | RIPK1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8070440 | 0.83 | RIPK1 (0.65) | RIPK1GPR88KCNQ3KCNQ2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | YAP1, TERF2IP, TEAD1 | RIPK1 595/4885GPR88 2587/4885KCNQ3 4740/4885 |
| US-20230174538-A1 | Tricyclic heterocycles | YAP1, TEAD1, TERF2IP | RIPK1 639/4885GPR88 2396/4885KCNQ3 4677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.