Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.58 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.58 |
| ▸ | CHRNG | P07510 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25587647 | 1.00 | CYP3A4 (0.60) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL25587649 | 1.00 | CYP3A4 (0.60) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL26465275 | 0.86 | CYP3A4 (0.66) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL24015601 | 0.86 | CYP3A4 (0.66) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL24016026 | 0.86 | CYP3A4 (0.66) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL25587874 | 0.83 | ALDH1A1 (0.41) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL25587650 | 0.83 | TP53 (0.44) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL25587643 | 0.83 | ALDH1A1 (0.41) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL25587645 | 0.83 | TP53 (0.44) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 | |
| SCHEMBL25587630 | 0.83 | RIPK1 (0.52) | CYP3A4CYP2C19ALDH1A1POLBCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | YAP1, TERF2IP, TEAD1 | CYP3A4 4382/4885CYP2C19 4791/4885ALDH1A1 3813/4885 |
| US-20230174538-A1 | Tricyclic heterocycles | YAP1, TEAD1, TERF2IP | CYP3A4 4072/4885CYP2C19 4683/4885ALDH1A1 3857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.