SCHEMBL2559396

SCHEMBL2559396

CC(=O)c1ccc(CC(Br)C(=O)O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.53
LMNA P02545 4/20 0.52
PPARG P37231 1/20 0.50
PPARA Q07869 1/20 0.50
HSD17B10 Q99714 1/20 0.47
ACACB O00763 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.43
ALDH1A1 P00352 2/20 0.43
MEN1 O00255 1/20 0.43
HPGD P15428 1/20 0.43
MMP12 P39900 1/20 0.43
MMP13 P45452 1/20 0.43
MAOB P27338 2/20 0.42
TPH1 P17752 1/20 0.42
MAPT P10636 1/20 0.42
SLC7A5 Q01650 1/20 0.42
PTGS1 P23219 3/20 0.41
PTGS2 P35354 3/20 0.41
CYP2C9 P11712 2/20 0.41
AKR1C3 P42330 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5372603 0.82 LOXL2 (0.56) KMT2AHSD17B10SMN1; SMN2ALDH1A1MEN1
SCHEMBL27828327 0.82 LOXL2 (0.56) KMT2AHSD17B10SMN1; SMN2ALDH1A1MEN1
SCHEMBL2033038 0.79 KMT2A (0.55) KMT2ALMNAPPARGPPARAHSD17B10
SCHEMBL93537 0.79 SLC7A5 (0.67) KMT2ALMNAPPARGPPARAHSD17B10
SCHEMBL12142803 0.79 KMT2A (0.55) KMT2ALMNAPPARGPPARAHSD17B10
SCHEMBL93538 0.79 SLC7A5 (0.67) KMT2ALMNAPPARGPPARAHSD17B10
SCHEMBL6777440 0.79 SLC7A5 (0.67) KMT2ALMNAPPARGPPARAHSD17B10
SCHEMBL19485698 0.79 KMT2A (0.55) KMT2ALMNAPPARGPPARAHSD17B10
SCHEMBL27807869 0.79 MME (0.51) KMT2APPARGPPARAMEN1LDHA
SCHEMBL4795941 0.79 SLC7A5 (0.60) SLC7A5ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed
EP-0592438-A1 INDOLE DERIVATIVES. PFIZER (US) 1994-04-20 EP disclosed
EP-0332331-B1 Thiazolidinedione hypoglycemic agents PFIZER (US) 1994-02-09 EP disclosed
US-5223522-A Anticholesterol agents PFIZER INC. (US) 1993-06-29 US disclosed
EP-0332332-B1 HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES PFIZER INC. (US) 1993-03-31 EP disclosed
US-5130379-A Anticholesterol agents and antidiabetic agents PFIZER INC. (US) 1992-07-14 US disclosed
US-5120754-A Anticholesterol and antidiabetic agents PFIZER INC. (US) 1992-06-09 US disclosed
US-5061717-A ANTICHOLESTEROL AGENTS PFIZER INC. (US) 1991-10-29 US disclosed
US-5036079-A Anticholesterol PFIZER INC. (US) 1991-07-30 US disclosed
WO-1991003474-A1 HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES PFIZER INC. (US) 1991-03-21 WO disclosed
WO-1989008650-A1 THIAZOLIDINEDIONE HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1989-09-21 WO disclosed
WO-1989008651-A1 HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES PFIZER INC. (US) 1989-09-21 WO disclosed
EP-0332332-A1 Hypoglycemic thiazolidinedione derivatives PFIZER INC. (US) 1989-09-13 EP disclosed
EP-0332331-A2 Thiazolidinedione hypoglycemic agents PFIZER INC. (US) 1989-09-13 EP disclosed