Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NT5E | P21589 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21277320 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 | |
| SCHEMBL24330941 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 | |
| SCHEMBL20180557 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 | |
| SCHEMBL14493125 | 0.74 | PTK2 (0.49) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 | |
| SCHEMBL28314009 | 0.73 | RAB9A (0.50) | SMN1; SMN2RAB9AKDM4EL3MBTL1KCNMA1 | |
| SCHEMBL2091200 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 | |
| SCHEMBL2091203 | 0.71 | FGFR1 (0.56) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 | |
| SCHEMBL241393 | 0.70 | IDO1 (0.54) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 | |
| SCHEMBL2627246 | 0.70 | KDM4E (0.64) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 | |
| SCHEMBL16596178 | 0.70 | NT5E (0.58) | SMN1; SMN2RAB9AKDM4ENPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030633-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-03-08 | — | — | WO | disclosed |