SCHEMBL25601566

SCHEMBL25601566

CC1(C)c2cc(C3(c4ccc(N5CCOCC5)cc4)C=Cc4c5c(c6ccccc6c4O3)-c3ccc(C(F)(F)F)cc3C5(C)C)ccc2-c2c1ccc1ccccc21

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 1/20 0.32
PDK2 Q15119 1/20 0.31
LRRK2 Q5S007 1/20 0.30
ALDH1A1 P00352 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
NTRK1 P04629 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25713633 0.95 CASR (0.31)
SCHEMBL25601564 0.94 PDK2 (0.33) PIK3CAPDK2LRRK2NTRK1
SCHEMBL25601561 0.94 PDK2 (0.33) PIK3CAPDK2LRRK2ALDH1A1SMN1; SMN2
SCHEMBL25601559 0.93 PDK2 (0.32) PIK3CAPDK2ALDH1A1NTRK1
SCHEMBL25713782 0.93 ALDH1A1 (0.34) PIK3CAPDK2LRRK2ALDH1A1SMN1; SMN2
SCHEMBL25601567 0.92 PDK2 (0.35) PIK3CAPDK2LRRK2
SCHEMBL25604301 0.92 PDK2 (0.32) PIK3CAPDK2ALDH1A1
SCHEMBL25845657 0.92 PDK2 (0.36) PIK3CAPDK2LRRK2ALDH1A1SMN1; SMN2
SCHEMBL25601557 0.91 PDK2 (0.38) PIK3CAPDK2LRRK2ALDH1A1SMN1; SMN2
SCHEMBL25844128 0.91 ALK (0.32) PIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4269532-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-11-01 EP disclosed
EP-4270067-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND GLASSES Hoya Lens Thailand Ltd. (TH) 2023-11-01 EP disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed
EP-4198102-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES NR2E3, CRY1, RPS10 PIK3CA 3076/4885PDK2 2722/4885LRRK2 1585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.