SCHEMBL25601770

SCHEMBL25601770

COC(=O)c1ccc(C2(c3ccc(OC)cc3)C=Cc3c4c(c5ccccc5c3O2)-c2ccc(C(F)(F)F)cc2C4(C)C)cc1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
MAPT P10636 4/20 0.35
KDM4E B2RXH2 2/20 0.34
MAOB P27338 1/20 0.34
POLB P06746 1/20 0.34
PDK2 Q15119 2/20 0.34
TP53 P04637 1/20 0.34
SCD O00767 1/20 0.34
PTGES O14684 1/20 0.34
GAA P10253 1/20 0.33
EIF4A1 P60842 1/20 0.33
CYP2C19 P33261 1/20 0.33
LMNA P02545 1/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25601064 0.93 CYP2C19 (0.33) RXFP1KDM4EMAOBTP53CYP2C19
SCHEMBL25601058 0.92 TP53 (0.34) RXFP1TP53CYP2C19LMNA
SCHEMBL25601793 0.90 NR1H4 (0.34) TDP1MAPTKDM4EPDK2TP53
SCHEMBL25601673 0.90 KIF11 (0.33) MAPTPTGESCYP2C19LMNA
SCHEMBL25601790 0.90 NR1H4 (0.34) TDP1MAPTKDM4EPDK2TP53
SCHEMBL25601250 0.90 MAPT (0.33) MAPTTP53CYP2C19LMNA
SCHEMBL25601676 0.90 CYP2C19 (0.32) CYP2C19LMNA
SCHEMBL25844158 0.90 TP53 (0.35) MAPTKDM4EPOLBTP53EIF4A1
SCHEMBL25601062 0.90 NR1H2 (0.33) MAPTKDM4ETP53CYP2C19LMNA
SCHEMBL25845183 0.89 NR1H4 (0.32) TDP1CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed
EP-4198583-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed
EP-4198102-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES NR2E3, CRY1, RPS10 RXFP1 274/4885TDP1 4097/4885MAPT 3015/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.