SCHEMBL2560299

SCHEMBL2560299

O=Cc1sc(Oc2ccc(C(F)(F)F)cc2)nc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.44
MAPT P10636 5/20 0.44
KMT2A Q03164 5/20 0.44
LMNA P02545 4/20 0.40
PSMD14 O00487 1/20 0.40
ALDH1A1 P00352 2/20 0.37
GLA P06280 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
NPBWR1 P48145 3/20 0.36
KCNH2 Q12809 2/20 0.35
SCN9A Q15858 2/20 0.35
KDM4E B2RXH2 2/20 0.35
SCN5A Q14524 1/20 0.35
POLB P06746 1/20 0.35
AHR P35869 1/20 0.34
ICAM1 P05362 2/20 0.34
SELE P16581 2/20 0.34
MCHR1 Q99705 1/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15331076 0.84 ALDH1A1 (0.48) MEN1MAPTKMT2ALMNAPSMD14
SCHEMBL2559484 0.84 MAPT (0.47) MEN1MAPTKMT2ALMNAPSMD14
SCHEMBL2563053 0.84 MEN1 (0.49) MEN1MAPTKMT2ALMNAPSMD14
SCHEMBL28715176 0.83 THRB (0.34) MAPTLMNAKCNH2SCN9AKDM4E
SCHEMBL2574517 0.81 MAPT (0.47) MEN1MAPTKMT2ALMNAPSMD14
SCHEMBL2554863 0.81 MAPT (0.57) MEN1MAPTKMT2ALMNAPSMD14
SCHEMBL2561164 0.81 MAPT (0.64) MEN1MAPTKMT2ALMNAPSMD14
SCHEMBL29956897 0.81 KMT2A (0.55) MEN1MAPTKMT2ALMNAPSMD14
SCHEMBL2556124 0.78 KMT2A (0.44) MEN1MAPTKMT2ALMNAPSMD14
SCHEMBL2555365 0.77 MEN1 (0.46) MEN1MAPTKMT2ALMNAPSMD14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed