Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27402031 | 0.89 | ADORA1 (0.49) | ADORA2AADORA1HRH3CYP11B1CYP11B2 | |
| SCHEMBL31739220 | 0.89 | ADORA1 (0.49) | ADORA2AADORA1HRH3CYP11B1CYP11B2 | |
| SCHEMBL16619272 | 0.84 | LOXL2 (0.52) | HRH3RAF1 | |
| SCHEMBL1413347 | 0.83 | LOXL2 (0.48) | ADORA2AADORA1HRH3CYP11B1CYP11B2 | |
| SCHEMBL7673123 | 0.83 | CYP11B1 (0.38) | ADORA2AADORA1HRH3CYP11B1CYP11B2 | |
| SCHEMBL29625378 | 0.83 | CYP11B1 (0.38) | ADORA2AADORA1HRH3CYP11B1CYP11B2 | |
| SCHEMBL1161457 | 0.83 | CYP11B1 (0.38) | ADORA2AADORA1HRH3CYP11B1CYP11B2 | |
| SCHEMBL19911768 | 0.83 | CYP11B2 (0.47) | ADORA2AADORA1HRH3CYP11B1CYP11B2 | |
| SCHEMBL1413419 | 0.83 | GRIN2B (0.40) | HRH3CYP11B1CYP11B2RAF1GRIN1 | |
| SCHEMBL1413439 | 0.83 | CYP11B1 (0.47) | ADORA2AADORA1HRH3CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |