Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | YAP1 | P46937 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557716 | 0.90 | EED (0.46) | GPR119KDM4EPKMYAP1ALDH1A1 | |
| SCHEMBL26635590 | 0.87 | GPR119 (0.47) | GPR119KDM4EPKMYAP1ALDH1A1 | |
| SCHEMBL26636545 | 0.87 | GPR119 (0.47) | GPR119KDM4EPKMYAP1ALDH1A1 | |
| SCHEMBL26636540 | 0.87 | GPR119 (0.47) | GPR119KDM4EPKMYAP1ALDH1A1 | |
| SCHEMBL26637294 | 0.87 | GPR119 (0.47) | GPR119KDM4EPKMYAP1ALDH1A1 | |
| SCHEMBL26635583 | 0.87 | GPR119 (0.47) | GPR119KDM4EPKMYAP1ALDH1A1 | |
| SCHEMBL1833006 | 0.85 | GPR119 (0.44) | GPR119KDM4EPKMALDH1A1MAPT | |
| SCHEMBL1296310 | 0.84 | GPR119 (0.63) | GPR119 | |
| SCHEMBL1296357 | 0.80 | GPR119 (0.48) | GPR119KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL7406884 | 0.80 | GPR119 (0.56) | GPR119KDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011128394-A1 | 3-SUBSTITUTED 5-(PYRROLIDINE-1-CARBONYL) PYRROLIDINE AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2011-10-20 | — | — | WO | disclosed |