SCHEMBL2560724

SCHEMBL2560724

OB(O)c1cccc(COc2ccc(Cl)c3ccccc23)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 5/20 0.55
ENPP2 Q13822 4/20 0.49
MRGPRX4 Q96LA9 6/20 0.45
F2 P00734 1/20 0.43
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.42
HPGD P15428 2/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
NPC1 O15118 1/20 0.42
MITF O75030 1/20 0.42
TP53 P04637 1/20 0.42
XBP1 P17861 1/20 0.42
NFKB1 P19838 1/20 0.42
RAB9A P51151 1/20 0.42
NFKB2 Q00653 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30518376 0.85 GPR84 (0.52) GPR84ENPP2F2KMT2AMEN1
SCHEMBL2554232 0.85 GPR84 (0.52) GPR84ENPP2F2KMT2AMEN1
SCHEMBL2557998 0.83 NPC1 (0.59) ENPP2MRGPRX4KMT2AMEN1HPGD
SCHEMBL25285122 0.82 MRGPRX4 (0.60) GPR84ENPP2MRGPRX4F2KMT2A
SCHEMBL29958263 0.82 MRGPRX4 (0.60) GPR84ENPP2MRGPRX4F2KMT2A
SCHEMBL2555006 0.81 MRGPRX4 (0.61) ENPP2MRGPRX4KMT2AMEN1HPGD
SCHEMBL2554070 0.81 MRGPRX4 (0.68) ENPP2MRGPRX4HPGDALDH1A1MAPT
SCHEMBL2560774 0.79 MRGPRX4 (0.60) ENPP2MRGPRX4KMT2AMEN1HPGD
SCHEMBL2557342 0.78 MRGPRX4 (0.53) ENPP2MRGPRX4KMT2AMEN1HPGD
SCHEMBL2559206 0.78 ENPP2 (0.52) ENPP2MRGPRX4KMT2AMEN1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed