Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566679 | 0.74 | ACACB (0.46) | HRH3PARP1CYP2D6PRMT5WDR77 | |
| SCHEMBL15881982 | 0.71 | HRH3 (0.52) | HRH3MAOAMAOBPARP1DRD2 | |
| SCHEMBL15880539 | 0.69 | HRH3 (0.47) | HRH3MAOAMAOBPARP1SMN1; SMN2 | |
| SCHEMBL15880537 | 0.69 | HRH3 (0.47) | HRH3MAOAMAOBPARP1SMN1; SMN2 | |
| SCHEMBL17311546 | 0.69 | HRH3 (0.47) | HRH3MAOAMAOBPARP1SMN1; SMN2 | |
| SCHEMBL5466386 | 0.67 | FPR2 (0.51) | HRH3MAOAMAOBSLC6A4SMN1; SMN2 | |
| SCHEMBL10686530 | 0.66 | MAOA (0.46) | HRH3MAOAMAOBPARP1SMN1; SMN2 | |
| SCHEMBL2561454 | 0.66 | HRH3 (0.46) | HRH3PARP1DRD2CYP2D6PRMT5 | |
| SCHEMBL13849617 | 0.65 | HRH3 (0.54) | HRH3SMN1; SMN2 | |
| SCHEMBL2560796 | 0.65 | DRD2 (0.50) | HRH3MAOAMAOBDRD2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960387-B1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | SANOFI SA (FR) | 2011-11-02 | — | — | EP | claimed |