Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25610970 | 1.00 | USP30 (0.45) | USP30EGLN2UCHL1S1PR1S1PR5 | |
| SCHEMBL25611309 | 0.87 | USP30 (0.49) | USP30EGLN2XDH | |
| SCHEMBL25611109 | 0.85 | USP30 (0.47) | USP30EGLN2UCHL1S1PR1S1PR5 | |
| SCHEMBL25611033 | 0.84 | USP30 (0.48) | USP30EGLN2UCHL1S1PR1S1PR5 | |
| SCHEMBL25611227 | 0.84 | UCHL1 (0.41) | USP30UCHL1S1PR1S1PR5WNT1 | |
| SCHEMBL25605336 | 0.83 | MKNK1 (0.59) | USP30UCHL1S1PR1S1PR5WNT1 | |
| SCHEMBL25613444 | 0.82 | XDH (0.43) | USP30UCHL1S1PR1S1PR5XDH | |
| SCHEMBL25611030 | 0.82 | XDH (0.38) | USP30UCHL1S1PR1S1PR5WNT1 | |
| SCHEMBL25610834 | 0.81 | ABL1 (0.45) | USP30UCHL1WNT1GSK3BDYRK1A | |
| SCHEMBL31272082 | 0.80 | S1PR1 (0.42) | USP30EGLN2S1PR1S1PR5XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107714-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |