SCHEMBL2561423

SCHEMBL2561423

OB(O)c1ccc(CSc2ccc(Cl)cc2)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 1/20 0.43
SOD1 P00441 1/20 0.38
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
ALDH1A1 P00352 3/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
DAO P14920 1/20 0.36
MAOA P21397 2/20 0.35
MAOB P27338 2/20 0.35
MAPT P10636 5/20 0.35
TDP1 Q9NUW8 3/20 0.35
HPGD P15428 3/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
TEAD1 P28347 1/20 0.34
YAP1 P46937 1/20 0.34
TEAD4 Q15561 1/20 0.34
TEAD2 Q15562 1/20 0.34
KDM4E B2RXH2 1/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29952791 0.88 DAO (0.38) ALDH1A1DAOMAOAMAOBLMNA
SCHEMBL29953808 0.85 CA2 (0.43) MEN1KMT2AALDH1A1NPC1RAB9A
SCHEMBL15331023 0.85 TDP1 (0.37) ENPP2MEN1KMT2ADAOMAOA
SCHEMBL2556147 0.77 KMT2A (0.38) KMT2AALDH1A1NPC1RAB9ADAO
SCHEMBL2558310 0.77 CXCR2 (0.40) SOD1MEN1KMT2AALDH1A1NPC1
SCHEMBL29956566 0.76 DHFR (0.38) MEN1KMT2AALDH1A1NPC1RAB9A
SCHEMBL29952084 0.75 CA1 (0.36) MEN1KMT2AALDH1A1NPC1RAB9A
SCHEMBL15332002 0.73 MAOB (0.45) ENPP2MEN1KMT2AALDH1A1MAOA
SCHEMBL2556038 0.72 MEN1 (0.49) SOD1MEN1KMT2AALDH1A1NPC1
SCHEMBL29957325 0.71 KMT2A (0.38) KMT2ANPC1RAB9ADAOMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed