SCHEMBL2561433

SCHEMBL2561433

OB(O)c1ccccc1COc1ccc(Cl)cc1Cl

nearest known ligand 0.60

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 12/20 0.60
ENPP2 Q13822 1/20 0.52
ADRB2 P07550 1/20 0.50
MAPT P10636 1/20 0.48
SLC6A2 P23975 2/20 0.46
SLC6A4 P31645 2/20 0.46
SLC6A3 Q01959 2/20 0.46
TDP1 Q9NUW8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2560808 0.88 ENPP2 (0.52) MRGPRX4ENPP2MAPTSLC6A4TDP1
SCHEMBL2556867 0.87 ENPP2 (0.51) MRGPRX4ENPP2MAPTSLC6A2SLC6A4
SCHEMBL2561997 0.87 MRGPRX4 (0.49) MRGPRX4ENPP2MAPT
SCHEMBL2557860 0.86 SLC6A2 (0.49) MRGPRX4ENPP2MAPTSLC6A2SLC6A4
SCHEMBL2561187 0.84 TP53 (0.56) MRGPRX4ENPP2MAPTSLC6A2SLC6A4
SCHEMBL2557709 0.82 ENPP2 (0.63) MRGPRX4ENPP2MAPT
SCHEMBL2558927 0.81 MAPT (0.46) MRGPRX4ENPP2MAPT
SCHEMBL11711706 0.80 MRGPRX4 (0.65) MRGPRX4ADRB2MAPTSLC6A2SLC6A3
SCHEMBL2558478 0.79 GPR84 (0.46) ENPP2MAPTTDP1
SCHEMBL2562456 0.78 MAOB (0.48) ENPP2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed