Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560814 | 0.93 | ALOX5 (0.47) | ALOX5LOXL2RAB9AHPGDCYP1A2 | |
| SCHEMBL2564245 | 0.83 | ALDH1A1 (0.43) | ALOX5LOXL2RAB9AHPGDCYP1A2 | |
| SCHEMBL2563304 | 0.82 | ALOX5 (0.41) | ALOX5LOXL2RAB9AHPGDCYP1A2 | |
| SCHEMBL2563607 | 0.80 | ALOX5 (0.46) | ALOX5LOXL2RAB9AHPGDMAPT | |
| SCHEMBL2561977 | 0.79 | ALOX5 (0.43) | ALOX5LOXL2RAB9AHPGDCYP1A2 | |
| SCHEMBL2566918 | 0.75 | TP53 (0.52) | ALOX5RAB9AHPGDHSD17B10MAPT | |
| SCHEMBL2564779 | 0.73 | ALOX5 (0.46) | ALOX5LOXL2RAB9AHPGDCYP1A2 | |
| SCHEMBL2551908 | 0.73 | ALOX5 (0.46) | ALOX5LOXL2RAB9AHPGDCYP1A2 | |
| SCHEMBL11587666 | 0.73 | ALOX5 (0.65) | ALOX5LOXL2RAB9AHPGDCYP1A2 | |
| SCHEMBL26698277 | 0.73 | CHRM3 (0.58) | MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |