Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 11/20 | 0.53 |
| ▸ | NPC1 | O15118 | 9/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559911 | 0.89 | LMNA (0.66) | KDM4ERAB9ANPC1LMNAMAPK1 | |
| SCHEMBL2557032 | 0.87 | KDM4E (0.56) | KDM4ERAB9ANPC1LMNAMAPK1 | |
| SCHEMBL2553329 | 0.85 | RAB9A (0.67) | KDM4ERAB9ANPC1LMNAMAPK1 | |
| SCHEMBL2557284 | 0.83 | F10 (0.56) | KDM4ERAB9ANPC1LMNAMAPK1 | |
| SCHEMBL2556997 | 0.82 | KDM4E (0.63) | KDM4ERAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL2562374 | 0.81 | RAB9A (0.59) | KDM4ERAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL2558993 | 0.81 | KDM4E (0.56) | KDM4ERAB9ANPC1LMNAMAPK1 | |
| SCHEMBL2560460 | 0.80 | KDM4E (0.61) | KDM4ERAB9ANPC1LMNAMAPK1 | |
| SCHEMBL2559582 | 0.80 | KDM4E (0.86) | KDM4ERAB9ANPC1LMNAMAPK1 | |
| SCHEMBL2557090 | 0.80 | KDM4E (0.63) | KDM4ERAB9ANPC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |