SCHEMBL25619902

SCHEMBL25619902

CS(=O)(=O)c1nc(Cl)c(Cl)c(I)n1

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25859859 0.84 SMN1; SMN2 (0.41) LMNASMN1; SMN2
SCHEMBL31513128 0.80 SMN1; SMN2 (0.39) LMNASMN1; SMN2
SCHEMBL7754111 0.78 LMNA (0.38) LMNASMN1; SMN2
SCHEMBL10584229 0.77 LMNA (0.36) LMNASMN1; SMN2
SCHEMBL12036842 0.75 SMN1; SMN2 (0.35) LMNASMN1; SMN2
SCHEMBL10583192 0.73 SMN1; SMN2 (0.40) LMNASMN1; SMN2
SCHEMBL10123082 0.73 LMNA (0.40) LMNASMN1; SMN2
SCHEMBL9626016 0.72 LMNA (0.33) LMNASMN1; SMN2
SCHEMBL4806359 0.71 SMN1; SMN2 (0.39) LMNASMN1; SMN2
SCHEMBL2960088 0.71 LMNA (0.39) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023099624-A1 ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2023-06-08 WO disclosed