Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.43 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.43 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503562 | 0.86 | PLK1 (0.52) | PLK1PLK3PLK2FLT3CSNK2A2 | |
| SCHEMBL25626292 | 0.81 | CHRM4 (0.39) | PLK1PLK3PLK2FLT3CSNK2A2 | |
| SCHEMBL20241977 | 0.79 | ACHE (0.46) | PLK1LMNATP53MAPTHPGD | |
| SCHEMBL409329 | 0.77 | PLK1 (0.45) | PLK1PLK3PLK2FLT3CSNK2A2 | |
| SCHEMBL25625317 | 0.75 | PLK1 (0.46) | PLK1PLK3PLK2FLT3CSNK2A2 | |
| SCHEMBL25626645 | 0.74 | HTR6 (0.46) | PLK1PLK3PLK2FLT3CSNK2A2 | |
| SCHEMBL1527209 | 0.72 | PLK1 (0.52) | PLK1PLK3PLK2FLT3CSNK2A2 | |
| SCHEMBL13249653 | 0.72 | HTR6 (0.48) | PLK1FLT3MAPTMAPK1 | |
| SCHEMBL11744961 | 0.72 | DRD2 (0.51) | CHRM4 | |
| SCHEMBL3505480 | 0.70 | KDR (0.46) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104178-A1 | PROTEIN KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 山东绿叶制药有限公司 | 2023-06-15 | — | — | WO | disclosed |