SCHEMBL2563022

SCHEMBL2563022

O=Cc1c(-c2ccc(F)cc2F)nn(-c2ccc(Cl)cc2)c1Br

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.41
IDO1 P14902 2/20 0.38
TDO2 P48775 2/20 0.38
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
ATM Q13315 1/20 0.36
SRC P12931 1/20 0.36
BRAF P15056 1/20 0.36
KDR P35968 1/20 0.36
PTGS1 P23219 1/20 0.35
PTGS2 P35354 1/20 0.35
AMY1A P0DUB6 1/20 0.34
CNR1 P21554 2/20 0.34
MIF P14174 1/20 0.34
MPI P34949 1/20 0.34
MAPK14 Q16539 2/20 0.34
MAPK13 O15264 1/20 0.34
MAPK12 P53778 1/20 0.34
MAPK11 Q15759 1/20 0.34
OXTR P30559 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15333169 0.93 MAPK14 (0.37) LMNAIDO1TDO2PTGS1PTGS2
SCHEMBL2562683 0.92 LMNA (0.41) LMNAIDO1TDO2MEN1KMT2A
SCHEMBL15331817 0.89 IDO1 (0.36) LMNAIDO1TDO2MEN1KMT2A
SCHEMBL2559746 0.88 TRPV1 (0.39) IDO1TDO2MEN1KMT2AMIF
SCHEMBL2561033 0.88 MAPK14 (0.42) LMNAMEN1KMT2ASRCBRAF
SCHEMBL15332463 0.86 MAPK14 (0.32) IDO1TDO2PTGS1PTGS2MAPK14
SCHEMBL15330295 0.85 P2RX7 (0.39) LMNAIDO1TDO2KMT2ACNR1
SCHEMBL2559144 0.85 LMNA (0.36) LMNAIDO1TDO2MEN1KMT2A
SCHEMBL2560741 0.84 ESR1 (0.40) IDO1TDO2MPIMAPK14MAPK13
SCHEMBL15331283 0.84 ESR1 (0.42) IDO1TDO2MAPK14MAPK13MAPK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed