Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 11/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | ILK | Q13418 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564043 | 0.87 | GRM4 (0.41) | GRM4KCNH2ILK | |
| SCHEMBL371068 | 0.76 | GRM4 (0.67) | GRM4KCNH2 | |
| SCHEMBL366515 | 0.63 | GRM4 (0.60) | GRM4KCNH2 | |
| SCHEMBL367422 | 0.62 | GRM4 (0.64) | GRM4KCNH2 | |
| SCHEMBL371066 | 0.61 | GRM4 (0.55) | GRM4KCNH2 | |
| SCHEMBL6837098 | 0.56 | GRM4 (0.83) | GRM4KCNH2 | |
| SCHEMBL366686 | 0.56 | GRM4 (1.00) | GRM4KCNH2 | |
| SCHEMBL18230269 | 0.55 | TGFBR1 (0.50) | — | |
| SCHEMBL6475329 | 0.53 | GRM4 (0.49) | GRM4KCNH2 | |
| SCHEMBL13516355 | 0.52 | LMNA (0.47) | ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382219-A1 | HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2011-11-02 | — | — | EP | disclosed |