Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | ILK | Q13418 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563052 | 0.87 | GRM4 (0.39) | GRM4KCNH2ILK | |
| SCHEMBL367422 | 0.67 | GRM4 (0.64) | GRM4KCNH2 | |
| SCHEMBL26246309 | 0.65 | ALDH1A1 (0.44) | TGFBR1KDM4EALDH1A1LMNAGAA | |
| SCHEMBL366515 | 0.65 | GRM4 (0.60) | GRM4KCNH2 | |
| SCHEMBL18230269 | 0.64 | TGFBR1 (0.50) | TGFBR1KDM4EALDH1A1 | |
| SCHEMBL3737029 | 0.59 | TGFBR1 (0.55) | TGFBR1KDM4ELMNA | |
| SCHEMBL31361561 | 0.59 | TGFBR1 (0.55) | TGFBR1KDM4ELMNA | |
| SCHEMBL18230509 | 0.59 | TGFBR1 (0.45) | TGFBR1KDM4E | |
| SCHEMBL4510667 | 0.59 | LMNA (0.56) | ILKTGFBR1MAPK14KDM4ELMNA | |
| SCHEMBL26246310 | 0.58 | MAPT (0.52) | TGFBR1ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382219-A1 | HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2011-11-02 | — | — | EP | claimed |
| EP-2382219-A1 | HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2011-11-02 | — | — | EP | disclosed |