Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Berberine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 10/20 | 0.98 |
| ▸ | BCHE known ✓ | P06276 | 9/20 | 0.98 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.98 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.98 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.98 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.98 |
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.98 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.98 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.98 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.98 |
| ▸ | EP300 | Q09472 | 6/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.98 |
| ▸ | MAPT | P10636 | 4/20 | 0.98 |
| ▸ | RAD52 | P43351 | 4/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.98 |
| ▸ | RXRA | P19793 | 2/20 | 0.98 |
| ▸ | HTT | P42858 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Berberine SCHEMBL17699306 | 1.00 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL15669190 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL30153843 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL29354144 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL25632 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL2538316 | 0.98 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL3686644 | 0.98 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL4894622 | 0.98 | BCHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL21462194 | 0.98 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL10709599 | 0.98 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7398 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075619-A | Shengshengshengyuhong ointment and preparation method thereof and medicinal film band-aid | — | 2026-05-26 | — | — | CN | claimed |
| CN-122074590-A | Preparation method of sheep Zhuang powder | — | 2026-05-26 | — | — | CN | claimed |
| CN-117305079-B | Method for detecting drug resistance heterogeneity of bacteria based on single-cell microfluidic system and application thereof | 天津现代创新中药科技有限公司 | 2026-05-22 | — | — | CN | claimed |
| CN-119074726-B | Berberine hydrochloride slow-release solid dispersion and preparation method thereof | 河北农业大学 | 2026-05-19 | — | — | CN | claimed |
| CN-118663218-B | Preparation method of composite material for adsorbing berberine hydrochloride electrolytic manganese slag and coke | 渤海大学 | 2026-05-19 | — | — | CN | claimed |
| US-20260130895-A1 | METABOLISM ENHANCING COMPOSITIONS | Red Mountain Med Spa, LLC (US) | 2026-05-14 | — | — | US | claimed |
| CN-121569888-A | Production method and application of bile acid and Chinese herbal medicine combined feed additive | 四川乾能生物科技有限公司 | 2026-02-27 | — | — | CN | claimed |
| CN-121574121-A | Eutectic of puerarin and berberine hydrochloride, preparation method, composition and application thereof | 南方医科大学 | 2026-02-27 | — | — | CN | claimed |
| US-12551470-B2 | Metabolism enhancing compositions | Red Mountain Med Spa, LLC (US) | 2026-02-17 | — | — | US | claimed |
| EP-4687937-A1 | COMPOSITION BASED ON PLANT EXTRACTS USEFUL FOR THE TREATMENT OF DYSLIPIDAEMIAS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2026-02-11 | — | — | EP | claimed |
| EP-0467276-B1 | Polymer scale preventive agent and method of preventing polymer scale deposition using the same | SHINETSU CHEMICAL CO (JP) | 1996-02-28 | — | — | EP | claimed |
| CN-1111146-A | Chinese herbal medicinal 'Weiyanling' for treatment of gastropathy | YANG CHUANGLAO (CN) | 1995-11-08 | — | — | CN | claimed |
| US-5432241-A | Process to prevent polymer scale adhesion using an aromatic compound and a salt of polyvinylsulfuric acid | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1995-07-11 | — | — | US | claimed |
| US-5430113-A | Coating polymerization vessel; product of condensation of amino- and nitro-aromatic compounds | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | claimed |
| EP-0571651-A1 | Polymer scale preventive agent, polymerization vessel effective in preventing polymer scale deposition and process for preparation of polymer | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1993-12-01 | — | — | EP | claimed |
| CN-1062088-A | PREPARATION TECHNOLOGY OF COLD RESISTANT PANACLA TABLET | SHENYANG TRADITIONAL CHINESE M (CN) | 1992-06-24 | — | — | CN | claimed |
| EP-0467311-A2 | Polymer scale preventive agent method of preventing polymer scale deposition using it | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1992-01-22 | — | — | EP | claimed |
| EP-0467276-A2 | Polymer scale preventive agent and method of preventing polymer scale deposition using the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1992-01-22 | — | — | EP | claimed |
| EP-0163924-B1 | VITAMIN MEDICINE FOR THE TREATMENT AND PROTECTION OF MUCOUS MEMBRANES, AND USE OF VITAMIN E FOR MANUFACTURING THE MEDICINE | Ismail, Roshdy, Dr. (DE) | 1991-12-18 | — | — | EP | claimed |
| CN-85100453-A | PROCESS OF MANUFACTURE OF XIANGLIAN TABLET | — | 1986-07-09 | — | — | CN | claimed |