Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.98 |
| ▸ | BCHE | P06276 | 9/20 | 0.98 |
| ▸ | EP300 | Q09472 | 6/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.98 |
| ▸ | MAPT | P10636 | 4/20 | 0.98 |
| ▸ | RAD52 | P43351 | 4/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.98 |
| ▸ | DRD2 | P14416 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 2/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.98 |
| ▸ | RXRA | P19793 | 2/20 | 0.98 |
| ▸ | DRD1 | P21728 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | HTT | P42858 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Berberine SCHEMBL30153843 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL25632 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL15669190 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL29354144 | 0.99 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL1376273 | 0.98 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL4894622 | 0.98 | BCHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL21462194 | 0.98 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL10709599 | 0.98 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL153906 | 0.98 | ACHE (1.00) | ACHEBCHEEP300CYP3A4MAPT | |
| Berberine SCHEMBL2538316 | 0.98 | ACHE (0.98) | ACHEBCHEEP300CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230404107-A1 | BERBERINE ALKALOIDS IN THE PREVENTION AND/OR TREATMENT OF INTESTINAL DISEASE | IRP Health Pty Ltd (AU) | 2023-12-21 | — | — | US | disclosed |
| WO-2023115158-A1 | COATING COMPOSITIONS | Silfresh Pty Ltd (AU) | 2023-06-29 | — | — | WO | disclosed |
| US-20210329946-A1 | BERBERINE ALKALOID FORMULATIONS IN THE PREVENTION AND/OR TREATMENT OF INFECTIOUS DISEASE | IRP Health Pty Ltd (AU) | 2021-10-28 | — | — | US | disclosed |
| US-20210220335-A1 | NITROIMIDAZOLE FORMULATIONS | IRP Health Pty Ltd (AU) | 2021-07-22 | — | — | US | disclosed |
| EP-3810137-A1 | NITROIMIDAZOLE FORMULATIONS | IRP Health Pty Ltd (AU) | 2021-04-28 | — | — | EP | disclosed |
| WO-2021072473-A1 | ANTIMICROBIALS AS FEED PRESERVATIVES | IRP Health Pty Ltd (AU) | 2021-04-22 | — | — | WO | disclosed |
| CN-112543635-A | Nitroimidazole formulations | IRP健康股份有限公司 | 2021-03-23 | — | — | CN | disclosed |
| EP-3600305-A1 | BERBERINE ALKALOID FORMULATIONS IN THE PREVENTION AND/OR TREATMENT OF INFECTIOUS DISEASE | IRP Health Pty Ltd (AU) | 2020-02-05 | — | — | EP | disclosed |
| EP-3600304-A1 | BERBERINE ALKALOIDS IN THE PREVENTION AND/OR TREATMENT OF INTESTINAL DISEASE | IRP Health Pty Ltd (AU) | 2020-02-05 | — | — | EP | disclosed |
| CN-110709080-A | Use of berberine alkaloid preparation in preventing and/or treating infectious diseases | IRP健康股份有限公司 | 2020-01-17 | — | — | CN | disclosed |
| CN-110650739-A | Use of berberine alkaloid in preventing and/or treating intestinal diseases | IRP健康股份有限公司 | 2020-01-03 | — | — | CN | disclosed |
| WO-2019227149-A1 | NITROIMIDAZOLE FORMULATIONS | IRP Health Pty Ltd (AU) | 2019-12-05 | — | — | WO | disclosed |
| WO-2019196955-A1 | HYDROPHILIC BERBERINE DERIVATIVE WITH R10 AND R11 CONNECTED AND APPLICATION THEREOF IN PREPARATION OF DRUGS | 中国医学科学院药物研究所 | 2019-10-17 | — | — | WO | disclosed |
| WO-2019196957-A1 | HYDROPHILIC BERBERINE-TYPE DERIVATIVE AND APPLICATION THEREOF IN PREPARING DRUG | 中国医学科学院药物研究所 | 2019-10-17 | — | — | WO | disclosed |
| WO-2018176093-A1 | BERBINE ALKALOID FORMULATIONS IN THE PREVENTION AND/OR TREATMENT OF INFECTIOUS DISEASE | IRICCORGPHARM PTY LTD (AU) | 2018-10-04 | — | — | WO | disclosed |
| WO-2018176079-A1 | BERBERINE ALKALOIDS IN THE PREVENTION AND/OR TREATMENT OF INTESTINAL DISEASE | IRICCORGPHARM PTY LTD (AU) | 2018-10-04 | — | — | WO | disclosed |
| US-20100292178-A1 | Method of treating non-insulin dependent diabetes mellitus and related complications | YOUNG JEFFREY | 2010-11-18 | — | — | US | disclosed |
| US-20050019435-A1 | Method of treating non-insulin dependent diabetes mellitus and related complications | YOUNG JEFFREY (US) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210220335-A1 | NITROIMIDAZOLE FORMULATIONS | PHB1, COX5B, CYP3A5 | ACHE 1722/4885BCHE 287/4885EP300 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.