Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23853811 | 0.92 | HTR1A (0.40) | HTR1ASLC6A2SLC6A4RIPK1OPRL1 | |
| SCHEMBL3784551 | 0.83 | HTR1A (0.55) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30516598 | 0.82 | P2RX7 (0.39) | HTR1ASLC6A2SLC6A4RIPK1OPRL1 | |
| SCHEMBL13229250 | 0.80 | SSTR4 (0.43) | HTR1A | |
| SCHEMBL18706367 | 0.80 | MAPT (0.39) | HTR1ASLC6A2SLC6A4RIPK1P2RX7 | |
| SCHEMBL31438527 | 0.78 | KDM4E (0.34) | HTR1ASLC6A2SLC6A4RIPK1KDM4E | |
| SCHEMBL25190850 | 0.78 | KDM4E (0.34) | HTR1ASLC6A2SLC6A4RIPK1KDM4E | |
| SCHEMBL14853258 | 0.78 | PDE4D (0.46) | RIPK1KDM4EL3MBTL1P2RX7 | |
| SCHEMBL27804796 | 0.78 | PDK2 (0.41) | HTR1ASLC6A2SLC6A4OPRL1CYP11B2 | |
| SCHEMBL29714391 | 0.77 | KDM4E (0.37) | HTR1ASLC6A2SLC6A4RIPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560653-A1 | CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | Cytokinetics, Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133888-A1 | CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. (US) | 2011-10-27 | — | — | WO | disclosed |