Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.65 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.64 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741176 | 0.85 | SIRT1 (0.72) | NPC1RAB9AMAPTSMN1; SMN2PTPN1 | |
| SCHEMBL24203622 | 0.85 | PTPN1 (0.69) | NPC1RAB9AMAPTSMN1; SMN2PTPN1 | |
| SCHEMBL126415 | 0.84 | PTPN1 (0.87) | NPC1RAB9AMAPTSMN1; SMN2PTPN1 | |
| SCHEMBL11495111 | 0.84 | EPHX1 (0.71) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL25812122 | 0.84 | RAB9A (0.76) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL23977686 | 0.84 | POLB (0.59) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2244112 | 0.83 | NPC1 (0.64) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL95932 | 0.83 | PLK1 (0.56) | NPC1RAB9AMAPTSMN1; SMN2CACNA1B | |
| SCHEMBL14715824 | 0.82 | NPC1 (0.88) | NPC1RAB9AMAPTSMN1; SMN2PTPN1 | |
| SCHEMBL18103163 | 0.82 | NPC1 (0.88) | NPC1RAB9AMAPTSMN1; SMN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104487433-B | Triazolone compounds as mPGES-1 inhibitors | 格兰马克药品股份有限公司 | 2016-12-07 | — | — | CN | disclosed |
| EP-2382194-A2 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE | RESVERLOGIX CORP. (CA) | 2011-11-02 | — | — | EP | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
| EP-0495626-A1 | Process for the preparation of tetrazole derivatives | ZENECA LIMITED (GB) | 1992-07-22 | — | — | EP | disclosed |