Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.76 |
| ▸ | NPC1 | O15118 | 9/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12310125 | 0.87 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL14580374 | 0.87 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL15214321 | 0.87 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL27181403 | 0.87 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL822378 | 0.87 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL23977686 | 0.86 | POLB (0.59) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2244112 | 0.85 | NPC1 (0.64) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL95932 | 0.85 | PLK1 (0.56) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL2563371 | 0.84 | NPC1 (0.66) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL7292377 | 0.83 | TRPV1 (0.71) | RAB9ANPC1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219893-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | US GOV VETERANS AFFAIRS (US) | 2023-07-13 | — | — | US | disclosed |
| US-11643394-B2 | Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11643394-B2 | Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease | KIF15, KLF5, KLF10 | RAB9A 1697/4885NPC1 834/4885SMN1; SMN2 45/4885 |
| US-20230219893-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | KIF15, KLF5, KLF10 | RAB9A 1697/4885NPC1 834/4885SMN1; SMN2 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.