Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564437 | 0.83 | KMT2A (0.51) | MAPTLMNASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL2563427 | 0.80 | KMT2A (0.48) | MAPTLMNASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL4498836 | 0.80 | MAPT (0.51) | MAPTLMNASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL27808153 | 0.77 | KDM4E (0.58) | MAPTLMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL12264890 | 0.77 | MAPT (1.00) | MAPTLMNASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL6256569 | 0.71 | AURKA (0.72) | MAPTLMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL2553897 | 0.71 | MEN1 (0.58) | MAPTLMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4501557 | 0.71 | ALDH1A1 (0.82) | MAPTLMNASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL22095227 | 0.71 | MAPT (0.88) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL976547 | 0.70 | AURKA (0.74) | MAPTLMNASMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552895-B1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | Westfälische Wilhelms Universität Münster (DE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2552895-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | Westfälische Wilhelms-Universität Münster (DE) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120861-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2011-10-06 | — | — | WO | disclosed |