Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25268440 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9ATSHRPKM | |
| SCHEMBL25214723 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9ATSHRPKM | |
| Hydrochloric Acid SCHEMBL25219926 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9ATSHRPKM | |
| Hydrochloric Acid SCHEMBL25273039 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9ATSHRPKM | |
| SCHEMBL8431597 | 0.81 | KMT2A (0.46) | SMN1; SMN2NPC1RAB9ATSHRPSMB5 | |
| SCHEMBL6641758 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9ATSHRPKM | |
| SCHEMBL12384285 | 0.77 | MTNR1A (0.58) | RAB9ACYP2D6MAPT | |
| SCHEMBL27926709 | 0.76 | LMNA (0.55) | SMN1; SMN2NPC1RAB9ATSHRPKM | |
| SCHEMBL29359016 | 0.76 | LMNA (0.55) | SMN1; SMN2NPC1RAB9ATSHRPKM | |
| SCHEMBL29582472 | 0.76 | NPC1 (0.44) | SMN1; SMN2NPC1RAB9ATSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107487-A1 | LONP1 INHIBITOR COMPOUNDS, USES AND METHODS | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |