Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30004999 | 1.00 | TAAR1 (0.38) | TAAR1GAAALDH1A1MEN1KMT2A | |
| SCHEMBL3414205 | 0.88 | TAAR1 (0.36) | TAAR1GAAL3MBTL1CNR1BACE1 | |
| SCHEMBL3824893 | 0.87 | TAAR1 (0.36) | TAAR1GAAALDH1A1CNR1BACE1 | |
| SCHEMBL3414495 | 0.86 | TAAR1 (0.35) | TAAR1GAAALDH1A1CNR1NOTUM | |
| SCHEMBL1358925 | 0.83 | NOTUM (0.42) | TAAR1GAAALDH1A1MEN1KMT2A | |
| SCHEMBL3414586 | 0.82 | CYP3A4 (0.39) | TAAR1GAAALDH1A1MEN1KMT2A | |
| SCHEMBL20103788 | 0.81 | TAAR1 (0.59) | TAAR1BACE1 | |
| SCHEMBL3414629 | 0.80 | TAAR1 (0.36) | TAAR1GAAALDH1A1MEN1KMT2A | |
| SCHEMBL3416805 | 0.80 | CYP1A2 (0.33) | NPSR1 | |
| SCHEMBL19112283 | 0.79 | TAAR1 (0.38) | TAAR1GAACYP2A13TNFRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448813-B | Method for preparing (S) -2, 6-dichloro-3-fluorophenylethanol | 中国科学院兰州化学物理研究所 | 2023-07-25 | — | — | CN | claimed |
| CN-111118072-A | Method for preparing enzatinib intermediate by enzyme method | 长兴制药股份有限公司 | 2020-05-08 | — | — | CN | claimed |
| CN-105906656-A | Synthetic method of crizotinib intermediate | 凯莱英医药集团（天津）股份有限公司 | 2016-08-31 | — | — | CN | claimed |
| CN-105272966-A | Preparation method of ALK inhibitor crizotinib and analogue or salt thereof | NANJING LEIKEXING BIOTECHNOLOGY CO LTD | 2016-01-27 | — | — | CN | claimed |
| CN-104058935-A | Preparation method of (S)-1-(2,6-dichloro-3-fluorophenyl) ethanol | ZHEJIANG ZHONGXIN CHEMICALS CO LTD | 2014-09-24 | — | — | CN | claimed |
| EP-2198018-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Codexis, Inc. (US) | 2010-06-23 | — | — | EP | claimed |
| WO-2009036404-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | CODEXIS, INC. (US) | 2009-03-19 | — | — | WO | claimed |
| EP-1791965-A1 | ENANTIOSELECTIVE BIOTRANSFORMATION FOR PREPARATION OF PROTEIN TYROSINE KINASE INHIBITOR INTERMEDIATES | Pfizer, Inc. (US) | 2007-06-06 | — | — | EP | claimed |
| WO-2006021885-A1 | ENANTIOSELECTIVE BIOTRANSFORMATION FOR PREPARATION OF PROTEIN TYROSINE KINASE INHIBITOR INTERMEDIATES | PFIZER INC. (US) | 2006-03-02 | — | — | WO | claimed |
| US-20060046287-A1 | Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates | AGOURON PHARMACEUTICALS, INC. | 2006-03-02 | — | — | US | claimed |
| CN-115448813-B | Method for preparing (S) -2, 6-dichloro-3-fluorophenylethanol | 中国科学院兰州化学物理研究所 | 2023-07-25 | — | — | CN | disclosed |
| CN-115448813-B | Method for preparing (S) -2, 6-dichloro-3-fluorophenylethanol | 中国科学院兰州化学物理研究所 | 2023-07-25 | — | — | CN | disclosed |
| CN-115448813-B | Method for preparing (S) -2, 6-dichloro-3-fluorophenylethanol | 中国科学院兰州化学物理研究所 | 2023-07-25 | — | — | CN | disclosed |
| CN-115448813-A | Method for preparing (S) -2, 6-dichloro-3-fluorophenethyl alcohol | 中国科学院兰州化学物理研究所 | 2022-12-09 | — | — | CN | disclosed |
| CN-115448813-A | Method for preparing (S) -2, 6-dichloro-3-fluorophenethyl alcohol | 中国科学院兰州化学物理研究所 | 2022-12-09 | — | — | CN | disclosed |
| EP-1959955-A2 | METHOD OF TREATING ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007066187-A2 | METHOD OF TREATING ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| EP-1791965-A1 | ENANTIOSELECTIVE BIOTRANSFORMATION FOR PREPARATION OF PROTEIN TYROSINE KINASE INHIBITOR INTERMEDIATES | Pfizer, Inc. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006021885-A1 | ENANTIOSELECTIVE BIOTRANSFORMATION FOR PREPARATION OF PROTEIN TYROSINE KINASE INHIBITOR INTERMEDIATES | PFIZER INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060046287-A1 | Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates | AGOURON PHARMACEUTICALS, INC. | 2006-03-02 | — | — | US | disclosed |