Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414205 | 0.94 | TAAR1 (0.36) | TAAR1GAACA2FFAR4TLR8 | |
| SCHEMBL2565042 | 0.86 | TAAR1 (0.38) | TAAR1GAAALDH1A1NOTUMCNR1 | |
| SCHEMBL30004999 | 0.86 | TAAR1 (0.38) | TAAR1GAAALDH1A1NOTUMCNR1 | |
| SCHEMBL1358925 | 0.78 | NOTUM (0.42) | TAAR1GAAALDH1A1NOTUMCNR1 | |
| SCHEMBL20103788 | 0.76 | TAAR1 (0.59) | TAAR1PNMT | |
| SCHEMBL19112283 | 0.75 | TAAR1 (0.38) | TAAR1GAA | |
| SCHEMBL16241904 | 0.74 | GPR17 (0.36) | TAAR1GAAFFAR4CNR1 | |
| SCHEMBL5294145 | 0.74 | TAAR1 (0.52) | TAAR1GAALMNATLR8 | |
| SCHEMBL3824893 | 0.74 | TAAR1 (0.36) | TAAR1GAACA2FFAR4ALDH1A1 | |
| SCHEMBL33527189 | 0.73 | DPP4 (0.38) | CA2ALDH1A1LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265616-A1 | FURO-AND THIENO[3,2-C]PYRIDINES | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009100282-A1 | FURO-AND THIENO[3,2-C] PYRIDINES | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |