Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805580 | 0.88 | P2RX7 (0.35) | TAAR1P2RX7FFAR4 | |
| SCHEMBL16241902 | 0.81 | TAAR1 (0.35) | TAAR1GAACNR1 | |
| SCHEMBL12825475 | 0.80 | MPO (0.35) | TAAR1PKMGAACNR1LMNA | |
| SCHEMBL29447983 | 0.80 | MPO (0.35) | TAAR1PKMGAACNR1LMNA | |
| SCHEMBL22031845 | 0.77 | TAAR1 (0.32) | TAAR1GAACNR1SMN1; SMN2 | |
| SCHEMBL21811824 | 0.77 | ERN1 (0.36) | TAAR1GAACNR1LMNAHTT | |
| SCHEMBL29457672 | 0.77 | TAAR1 (0.32) | TAAR1GAACNR1SMN1; SMN2 | |
| SCHEMBL25180090 | 0.77 | TAAR1 (0.36) | TAAR1PKMGAACNR1LMNA | |
| SCHEMBL29569478 | 0.76 | TAAR1 (0.55) | TAAR1PKMGAACNR1LMNA | |
| SCHEMBL1460113 | 0.76 | TAAR1 (0.55) | TAAR1PKMGAACNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111118072-A | Method for preparing enzatinib intermediate by enzyme method | 长兴制药股份有限公司 | 2020-05-08 | — | — | CN | claimed |
| CN-111118072-A | Method for preparing enzatinib intermediate by enzyme method | 长兴制药股份有限公司 | 2020-05-08 | — | — | CN | disclosed |
| CN-111118072-A | Method for preparing enzatinib intermediate by enzyme method | 长兴制药股份有限公司 | 2020-05-08 | — | — | CN | disclosed |
| WO-2014193647-A2 | ALKENYL COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2014-12-04 | — | — | WO | disclosed |
| EP-2381777-A1 | AZAINDOLE DERIVATIVES AS KINASE INHIBITORS | ARIAD Pharmaceuticals, Inc (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010068292-A1 | AZAINDOLE DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |