Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.36 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.31 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21812009 | 0.84 | DPP4 (0.39) | ERN1MEP1AMEP1BDPP4MAPT | |
| SCHEMBL18191222 | 0.81 | GABRA1 (0.35) | MEP1AMEP1BDPP4GAACNR1 | |
| SCHEMBL12825475 | 0.81 | MPO (0.35) | GAACNR1BACE1KDM4ETAAR1 | |
| SCHEMBL29447983 | 0.81 | MPO (0.35) | GAACNR1BACE1KDM4ETAAR1 | |
| SCHEMBL21811819 | 0.81 | CYP3A4 (0.37) | ERN1MEP1AMEP1BDPP4PIK3CA | |
| SCHEMBL21822850 | 0.79 | HTR3E (0.36) | MEP1BDPP4GAAKDM4EMAPT | |
| SCHEMBL430975 | 0.78 | ERN1 (0.36) | ERN1MEP1AMEP1BAR | |
| SCHEMBL22031845 | 0.78 | TAAR1 (0.32) | GAACNR1TAAR1SMN1; SMN2 | |
| SCHEMBL21811818 | 0.78 | DPP4 (0.34) | ERN1MEP1AMEP1BDPP4MAPT | |
| SCHEMBL29457672 | 0.78 | TAAR1 (0.32) | GAACNR1TAAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849966-A1 | FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. Hoffmann-La Roche AG (CH) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020053249-A1 | FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-19 | — | — | WO | disclosed |