Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 4/20 | 0.41 |
| ▸ | CTSD | P07339 | 3/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175480 | 0.79 | LMNA (0.48) | LMNAMAPTACHEALDH1A1KDM4E | |
| SCHEMBL6694692 | 0.78 | DNM1 (0.54) | LMNAMAPTALDH1A1GAADNM1 | |
| SCHEMBL5219603 | 0.78 | DNM1 (0.54) | LMNAMAPTALDH1A1GAADNM1 | |
| Hydrochloric Acid SCHEMBL5219543 | 0.78 | LMNA (0.47) | LMNAMAPTACHEALDH1A1KDM4E | |
| SCHEMBL5930378 | 0.74 | CYP1A2 (0.56) | LMNAACHEALDH1A1HPGD | |
| SCHEMBL5930107 | 0.73 | SMN1; SMN2 (0.48) | LMNAMAPTALDH1A1GAADNM1 | |
| SCHEMBL5223199 | 0.71 | LMNA (0.46) | LMNAMAPTACHEALDH1A1GAA | |
| SCHEMBL5223191 | 0.71 | LMNA (0.46) | LMNAMAPTACHEALDH1A1GAA | |
| SCHEMBL5391448 | 0.71 | ABCB1 (0.53) | LMNAALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL15101698 | 0.71 | DNM1 (0.53) | LMNAALDH1A1KDM4EBACE1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |