Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 9/20 | 0.45 |
| ▸ | CTSD | P07339 | 3/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223199 | 1.00 | LMNA (0.46) | LMNABACE1CTSDBACE2MAPT | |
| SCHEMBL5222219 | 0.88 | OPRM1 (0.47) | BACE1CTSDBACE2BCHEOPRM1 | |
| SCHEMBL5222213 | 0.88 | OPRM1 (0.47) | BACE1CTSDBACE2BCHEOPRM1 | |
| SCHEMBL175480 | 0.78 | LMNA (0.48) | LMNABACE1CTSDBACE2MAPT | |
| SCHEMBL717681 | 0.77 | ATM (0.53) | BACE1CTSDBACE2BCHEATM | |
| SCHEMBL717679 | 0.77 | ATM (0.53) | BACE1CTSDBACE2BCHEATM | |
| Hydrochloric Acid SCHEMBL5219543 | 0.77 | LMNA (0.47) | LMNABACE1CTSDBACE2MAPT | |
| SCHEMBL609656 | 0.77 | ANPEP (0.42) | BACE1MAPTBCHEOPRM1KMT2A | |
| SCHEMBL609658 | 0.77 | ANPEP (0.42) | BACE1MAPTBCHEOPRM1KMT2A | |
| SCHEMBL5220912 | 0.76 | REN (0.40) | BACE1CTSDBCHEOPRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |