Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2992411 | 0.81 | LMNA (0.38) | LMNAPOLBTDP1GAAALDH1A1 | |
| SCHEMBL19267936 | 0.79 | POLB (0.41) | LMNAPOLBMEN1TSHRKMT2A | |
| SCHEMBL3469611 | 0.79 | TSHR (0.42) | LMNAPOLBMEN1HPGDTSHR | |
| SCHEMBL562875 | 0.76 | — | — | |
| Water SCHEMBL28132242 | 0.73 | — | — | |
| SCHEMBL28635486 | 0.73 | — | — | |
| SCHEMBL2485153 | 0.73 | CYP3A4 (0.48) | TSHRALDH1A1 | |
| SCHEMBL51192 | 0.72 | LMNA (0.46) | LMNAPOLBMEN1HPGDTSHR | |
| SCHEMBL10946943 | 0.72 | — | — | |
| SCHEMBL18096846 | 0.71 | ALDH1A1 (0.52) | LMNAMEN1TSHRKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183707-A1 | COMPOSITIONS AND METHODS FOR INHIBITING MARC1 GENE EXPRESSION | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-06-15 | — | — | US | disclosed |