Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 11/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563232 | 1.00 | MAPT (0.61) | MAPTALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL2565389 | 0.84 | NPC1 (0.62) | MAPTALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL2563450 | 0.84 | NPC1 (0.62) | MAPTALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL27494737 | 0.79 | TSHR (0.51) | MAPTALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL2561682 | 0.79 | RAB9A (0.67) | MAPTALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL31065689 | 0.74 | ALDH1A1 (0.66) | MAPTALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL1197272 | 0.73 | TSHR (0.56) | MAPTALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL1197702 | 0.73 | TSHR (0.56) | MAPTALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL12965878 | 0.73 | PTPN1 (0.59) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1094083 | 0.73 | NPC1 (0.63) | MAPTTP53SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011131975-A1 | MICROSOMAL PROSTAGLANDIN E SYNTASE-1 INHIBITORS | Convergence Pharmaceuticals Limited (GB) | 2011-10-27 | — | — | WO | disclosed |