Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 8/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562824 | 0.86 | RAB9A (0.74) | RAB9AMAPTUSP2MEN1KMT2A | |
| SCHEMBL2563232 | 0.79 | MAPT (0.61) | RAB9AMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL2565666 | 0.79 | MAPT (0.61) | RAB9AMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL628100 | 0.73 | MAPT (0.54) | MAPTNPSR1SMN1; SMN2TP53THRB | |
| SCHEMBL2566408 | 0.73 | SMN1; SMN2 (0.73) | RAB9AMAPTUSP2MEN1KMT2A | |
| SCHEMBL2577770 | 0.73 | SMN1; SMN2 (0.73) | RAB9AMAPTUSP2MEN1KMT2A | |
| SCHEMBL628099 | 0.70 | ALDH1A1 (0.49) | RAB9AMAPTUSP2MEN1KMT2A | |
| SCHEMBL24873099 | 0.70 | ALDH1A1 (0.66) | RAB9AMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4684573 | 0.69 | ALDH1A1 (0.58) | RAB9AMAPTUSP2MEN1KMT2A | |
| SCHEMBL3436332 | 0.69 | ALDH1A1 (0.63) | MAPTUSP2MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011131975-A1 | MICROSOMAL PROSTAGLANDIN E SYNTASE-1 INHIBITORS | Convergence Pharmaceuticals Limited (GB) | 2011-10-27 | — | — | WO | disclosed |