Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8462433 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBKMT2AHPGDCDC25B | |
| SCHEMBL8464513 | 0.78 | KDM4E (0.55) | POLBKMT2AHPGDKDM4EMEN1 | |
| SCHEMBL4400139 | 0.77 | HMGB1 (0.55) | SMN1; SMN2POLBKMT2AHPGDCYP3A4 | |
| SCHEMBL384123 | 0.77 | POLB (0.57) | SMN1; SMN2POLBKMT2AHPGDCYP3A4 | |
| SCHEMBL8464696 | 0.77 | TPMT (0.43) | SMN1; SMN2KMT2AHPGDKDM4EMEN1 | |
| SCHEMBL28493002 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBKMT2AHPGDCYP3A4 | |
| SCHEMBL1809647 | 0.75 | LCK (0.46) | SMN1; SMN2POLBKMT2AHPGDCYP3A4 | |
| SCHEMBL29260206 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBKMT2AHPGDCYP3A4 | |
| SCHEMBL27974265 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBKMT2AHPGDCYP3A4 | |
| SCHEMBL2565863 | 0.72 | CDC25B (0.43) | SMN1; SMN2POLBKMT2AHPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844088-B2 | Process for the preparation of estetrol | ESTETRA SPRL (BE) | 2020-11-24 | — | — | US | claimed |
| EP-2734536-B1 | PROCESS FOR THE PREPARATION OF ESTETROL | DONESTA BIOSCIENCE B V (NL) | 2016-09-28 | — | — | EP | claimed |
| US-10844088-B2 | Process for the preparation of estetrol | ESTETRA SPRL (BE) | 2020-11-24 | — | — | US | disclosed |
| US-20170369521-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | DONESTA BIOSCIENCE B.V. (NL) | 2017-12-28 | — | — | US | disclosed |
| EP-2734536-B1 | PROCESS FOR THE PREPARATION OF ESTETROL | DONESTA BIOSCIENCE B V (NL) | 2016-09-28 | — | — | EP | disclosed |
| US-20140235882-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | Pantarhei Biocience B.V. | 2014-08-21 | — | — | US | disclosed |
| EP-2734536-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | Pantarhei Bioscience B.V. (NL) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013012328-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | PANTARHEI BIOSCIENCE B.V. (NL) | 2013-01-24 | — | — | WO | disclosed |
| EP-2383279-A1 | Process for the preparation of estetrol | Pantarhei Bioscience B.V. (NL) | 2011-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369521-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | HSD17B11, CYP19A1, SULT1A1 | SMN1; SMN2 1666/4885POLB 1265/4885KMT2A 1566/4885 |
| US-10844088-B2 | Process for the preparation of estetrol | HSD17B11, CYP19A1, SULT1A1 | SMN1; SMN2 1538/4885POLB 1502/4885KMT2A 1356/4885 |
| US-20140235882-A1 | PROCESS FOR THE PREPARATION OF ESTETROL | CYP19A1, HSD17B11, SULT1A1 | SMN1; SMN2 1553/4885POLB 1769/4885KMT2A 1392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.