Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27639734 | 0.75 | NAAA (0.53) | GAACYP2C9CYP2C19CTSKCTSL | |
| SCHEMBL15715059 | 0.73 | GAA (0.49) | GAACYP2C9CYP2C19SMN1; SMN2HSD17B10 | |
| SCHEMBL27639742 | 0.71 | GAA (0.51) | GAACYP2C9CYP2C19SMN1; SMN2HSD17B10 | |
| SCHEMBL24568205 | 0.70 | GAA (0.47) | GAACYP2C9CYP2C19SMN1; SMN2HSD17B10 | |
| SCHEMBL15961740 | 0.70 | TP53 (0.49) | GAASMN1; SMN2ACACBALDH1A1 | |
| SCHEMBL23253780 | 0.69 | GAA (0.46) | GAACYP2C9CYP2C19SMN1; SMN2HSD17B10 | |
| SCHEMBL19927899 | 0.69 | GAA (0.46) | GAACYP2C9CYP2C19SMN1; SMN2HSD17B10 | |
| SCHEMBL21516188 | 0.68 | MEN1 (0.46) | GAACYP2C9CYP2C19SMN1; SMN2ACACB | |
| SCHEMBL24567736 | 0.68 | GAA (0.61) | GAACYP2C9CYP2C19SMN1; SMN2HSD17B10 | |
| SCHEMBL10308293 | 0.68 | GAA (0.61) | GAACYP2C9CYP2C19SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | GAA 74/4885CYP2C9 1880/4885CYP2C19 969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.