Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566640 | 0.80 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1ALOX5PDE10APDE4A | |
| SCHEMBL7594815 | 0.79 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1ALOX5ALOX5APPDE10A | |
| SCHEMBL7599131 | 0.78 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1ALOX5ALOX5APPDE10A | |
| SCHEMBL7599144 | 0.78 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1ALOX5ALOX5APPDE10A | |
| SCHEMBL7604022 | 0.77 | ALOX5 (0.57) | CYSLTR2CYSLTR1ALOX5ALOX5APPDE10A | |
| SCHEMBL22804522 | 0.77 | CYP1A2 (0.37) | CYSLTR2CYSLTR1 | |
| SCHEMBL7599134 | 0.75 | PDE4A (0.46) | CYSLTR2CYSLTR1ALOX5ALOX5APPDE10A | |
| SCHEMBL2564677 | 0.75 | PDE10A (0.54) | CYSLTR2CYSLTR1ALOX5PDE10APDE4A | |
| SCHEMBL8669638 | 0.74 | ALOX5 (0.54) | CYSLTR2CYSLTR1ALOX5ALOX5APPDE10A | |
| SCHEMBL8669643 | 0.74 | CYSLTR1 (0.72) | CYSLTR2CYSLTR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132048-A1 | HETEROARYL COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |