Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.57 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557903 | 0.87 | ALOX5 (0.56) | ALOX5CYSLTR2CYSLTR1HDAC6GPBAR1 | |
| SCHEMBL8557925 | 0.87 | ALOX5 (0.56) | ALOX5CYSLTR2CYSLTR1HDAC6GPBAR1 | |
| SCHEMBL8669638 | 0.85 | ALOX5 (0.54) | ALOX5CYSLTR2CYSLTR1HDAC6GPBAR1 | |
| SCHEMBL9556749 | 0.83 | ALOX5 (0.74) | ALOX5HDAC6ALOX5AP | |
| SCHEMBL7603712 | 0.83 | GPBAR1 (0.70) | ALOX5CYSLTR2CYSLTR1HDAC6GPBAR1 | |
| SCHEMBL2566640 | 0.81 | CYSLTR2 (0.56) | ALOX5CYSLTR2CYSLTR1GPBAR1PDE10A | |
| SCHEMBL8557912 | 0.81 | ALOX5 (0.55) | ALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL2564677 | 0.78 | PDE10A (0.54) | ALOX5CYSLTR2CYSLTR1PDE10APDE4A | |
| SCHEMBL2566437 | 0.77 | CYSLTR2 (0.53) | ALOX5CYSLTR2CYSLTR1GPBAR1PDE10A | |
| SCHEMBL8669643 | 0.77 | CYSLTR1 (0.72) | ALOX5CYSLTR2CYSLTR1FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | claimed |
| US-5795900-A | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-08-18 | — | — | US | claimed |
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | disclosed |
| US-5843968-A | Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-12-01 | — | — | US | disclosed |
| US-5795900-A | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-08-18 | — | — | US | disclosed |